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another long term side effect can be tolerance. kratom use has been linked to serious side effects including hallucinations, seizures, liver damage, withdrawal, and death. due to these and other serious safety concerns, the u. health problems from using kratom long term. there have been many reported health problems associated with long- term or heavy kratom use. a lot of these sky are discounted by kratom promoters because there haven’ t been any real clinical studies on kratom.